Kisspeptin 5mg 10mL Vial
$350.00
|$315 with Automatic Refills
Kisspeptin-10 is a peptide that activates the GPR54 receptor, a key regulator of the hypothalamic-pituitary-gonadal (HPG) axis. It’s being studied for its role in stimulating reproductive hormone release and supporting fertility, sexual function, and hormonal balance.
MOA
- Hypothalamic Pituitary Gonadal (HPG) Axis Regulation:
- Kisspeptin is a hypothalamic neuropeptide encoded by the KISS1 gene that exerts its primary physiological role in reproductive regulation. It binds to the G-protein–coupled receptor KISS1R (GPR54), which is expressed predominantly on gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus.
- GnRH Stimulation and Gonadotropin Secretion:
- Activation of KISS1R initiates intracellular phospholipase C (PLC) signaling, resulting in increased intracellular Ca²⁺ and the pulsatile release of GnRH into the hypophyseal portal system. GnRH then acts on the anterior pituitary to stimulate secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate sex steroidogenesis (testosterone in males; estrogen and progesterone in females) and gametogenesis (spermatogenesis and oogenesis).
- Integration of Metabolic and Reproductive Signaling:
- Kisspeptin serves as a key integrator of energy status and reproductive function. It interacts with leptin and insulin pathways, linking metabolic cues and energy availability to reproductive axis activation. This ensures fertility processes are synchronized with nutritional and environmental conditions.
- Neuroendocrine and Behavioral Modulation:
- Beyond reproductive regulation, Kisspeptin influences neuroendocrine signaling, mood, and sexual behavior through its action on hypothalamic and limbic brain regions. These neuromodulatory effects contribute to libido, affective balance, and reproductive motivation.
- HPG Axis Homeostasis and Stress Adaptation:
- Kisspeptin signaling plays a vital role in maintaining HPG axis homeostasis by modulating GnRH pulse frequency and amplitude in response to stress and hormonal feedback. This adaptive regulation supports reproductive resilience and endocrine stability across varying physiological states.
More Information
- Disclaimer: For Research Purposes Only – All products on this site are for Research and Development use only. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease. Celia Health is a supplier of research-use chemicals manufactured in a CGMP facility in the US. Celia Health is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act.
This product requires a prescription. After purchasing, you will receive instructions to schedule and complete your intake exam before your order can be fulfilled. Prescriptions are valid for one calendar year.
