Klotho 10mg Lyophilized Powder
$1800
|$1620 with Automatic Refills
6 week supply
Rx
Klotho-FG is a recombinant form of the Klotho protein, studied for its role in healthy aging, brain and kidney function, and metabolic regulation. It works by enhancing FGF23 signaling and modulating oxidative stress, calcium balance, and cellular repair pathways.
Refill Program Details:
One refill every every month for 12 months
MOA
- Klotho-FG Axis and FGF Signaling
- FGF23 (with α-Klotho) – Regulation of Phosphate and Calcium Metabolism
- Produced by bone osteocytes and acts on the kidneys
- Requires α-Klotho to bind to FGFRs and suppress renal phosphate reabsorption and vitamin D synthesis
- FGF19 and FGF21 (with β-Klotho) – Metabolic Regulation
- FGF19: Regulates bile acid metabolism, reduces bile acid synthesis, increases glycogen storage, and improves insulin sensitivity
- FGF21: Enhances glucose uptake, increases lipolysis and fatty acid oxidation, and promotes thermogenesis
- FGF23 (with α-Klotho) – Regulation of Phosphate and Calcium Metabolism
- Binding and Signal Transduction
- Klotho as a Co-Receptor
- Klotho proteins increase FGF binding affinity to FGFRs
- Forms FGFR-Klotho-FGF complex that stabilizes receptor-ligand interaction
- FGFR Activation
- Ligand binding induces FGFR dimerization and autophosphorylation
- Activates intracellular pathways:
- MAPK/ERK – regulates gene expression for metabolism and growth
- PI3K/AKT – promotes cellular survival and energy metabolism
- STAT – regulates inflammatory response and cell proliferation
- Klotho as a Co-Receptor
- Biological Effects
- Phosphate and Calcium Regulation (FGF23 + α-Klotho)
- Decreases renal phosphate reabsorption by downregulating Na+/Pi cotransporters
- Suppresses 1,25-dihydroxyvitamin D production, reducing calcium and phosphate absorption in the gut
- Metabolic Regulation (FGF19/FGF21 + β-Klotho)
- FGF19: Inhibits bile acid synthesis, increases glycogen storage, reduces gluconeogenesis
- FGF21: Enhances glucose uptake, stimulates fatty acid oxidation and thermogenesis
- Phosphate and Calcium Regulation (FGF23 + α-Klotho)
More Information
- Disclaimer: For Research Purposes Only – All products on this site are for Research and Development use only. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease. Celia Health is a supplier of research-use chemicals manufactured in a CGMP facility in the US. Celia Health is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act.
This product requires a prescription. After purchasing, you will receive instructions to schedule and complete your intake exam before your order can be fulfilled. Prescriptions are valid for one calendar year.
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