MOTS-C 10mg 10mL Vial
$995
MOTS-c is a mitochondrial-derived peptide being studied for its potential to support metabolic function, increase energy, and promote healthy aging by regulating cellular stress and enhancing fat metabolism.
MOA
- Activation of AMPK and Metabolic Regulation:
- MOTS-c activates AMP-activated protein kinase (AMPK), a central energy sensor that regulates cellular energy homeostasis. AMPK activation enhances glucose uptake, fatty acid oxidation, and mitochondrial biogenesis—improving energy balance during metabolic stress and supporting efficient ATP production.
- Folate Cycle Inhibition and Glycolytic Shift:
- By suppressing the folate cycle, MOTS-c redirects cellular metabolism toward glycolysis and away from mitochondrial oxidative phosphorylation. This adaptive shift helps preserve ATP levels and sustain energy output under stress conditions.
- Nuclear-Mitochondrial Communication:
- Under metabolic stress, MOTS-c translocates from the mitochondria to the nucleus, where it interacts with transcriptional regulators to influence gene expression related to metabolism, antioxidant defense, and cellular resilience. This nuclear signaling bridges mitochondrial function with genomic response to stress.
- Insulin Sensitivity and Glucose Homeostasis:
- MOTS-c exerts insulin-mimetic effects by enhancing GLUT4 translocation to the cell membrane, facilitating glucose uptake into skeletal muscle and adipose tissue. This action improves insulin sensitivity and contributes to stable glucose regulation.
- Anti-Inflammatory and Cytoprotective Actions:
- MOTS-c downregulates pro-inflammatory signaling pathways, including NF-κB activation, thereby reducing chronic inflammation and oxidative stress. These effects protect metabolic tissues and support overall cellular longevity.
- Mitochondrial Function and Stress Adaptation:
- By enhancing mitochondrial efficiency and promoting biogenesis, MOTS-c improves cellular energy metabolism and stress tolerance. This contributes to improved metabolic flexibility, endurance, and protection against metabolic dysfunction.
More Information
- Disclaimer: For Research Purposes Only – All products on this site are for Research and Development use only. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease. Celia Health is a supplier of research-use chemicals manufactured in a CGMP facility in the US. Celia Health is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act.
This product requires a prescription. After purchasing, you will receive instructions to schedule and complete your intake exam before your order can be fulfilled. Prescriptions are valid for one calendar year.
