NAD+ is a vital coenzyme being studied for its role in cellular energy production, mitochondrial function, and healthy aging. It may also support DNA repair, cognitive performance, and neuroprotection.
Benefits
May support cellular energy and metabolic function
May enhance DNA repair and promote longevity
May improve cognitive performance and neural plasticity
May help reduce neuroinflammation
Dosing
Cognitive benefits: 10-20mg
3-6 sprays in the AM
3-5x per week
Mitochondrial/Anti-Aging: 10-30mg
3-9 sprays in the AM
3x per week
How to Use
Duration: 3 months
1-month on, 1-week cycle break; repeat x2 more months
MOA
Mitochondrial Energy Production:
NAD+ functions as a critical redox cofactor in cellular energy metabolism. Within the mitochondrial electron transport chain, NAD+ accepts and donates electrons through oxidative phosphorylation, driving ATP generation and sustaining cellular energy balance. This process is essential for mitochondrial efficiency and overall metabolic vitality.
DNA Repair and Longevity Pathways:
NAD+ serves as a required substrate for poly(ADP-ribose) polymerase (PARP) enzymes involved in DNA repair and genomic stability. It also activates sirtuin deacetylases (SIRT1–SIRT7), key regulators of mitochondrial biogenesis, inflammation control, circadian rhythm, and metabolic homeostasis. Through these pathways, NAD+ supports cellular longevity and resilience under stress.
Neurocognitive and Neuroprotective Support:
By maintaining neuronal redox balance and activating sirtuin signaling, NAD+ enhances neuronal energy metabolism, neurotransmitter synthesis, and synaptic function. These effects promote cognitive clarity, mitochondrial protection, and improved neuronal recovery following oxidative or metabolic stress.
Immune Regulation and Inflammatory Control:
NAD+ helps preserve immune function by counteracting depletion caused by CD38 enzyme activity, which increases with age and inflammation. Sustaining intracellular NAD+ levels supports immune cell metabolism, cytokine regulation, and mitochondrial-driven immune responses, reducing inflammatory burden and supporting immune resilience.
Cellular Homeostasis and Aging Defense:
As a master metabolic cofactor, NAD+ integrates energy metabolism, DNA repair, and cellular defense systems. Restoration of NAD+ levels enhances mitochondrial communication, promotes autophagy, and combats metabolic decline associated with aging and chronic disease.
More Information
Disclaimer: For Research Purposes Only – All products on this site are for Research and Development use only. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease. Celia Health is a supplier of research-use chemicals manufactured in a CGMP facility in the US. Celia Health is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act.
This product requires a prescription. After purchasing, you will receive instructions to schedule and complete your intake exam before your order can be fulfilled. Prescriptions are valid for one calendar year.