Oxytocin & Methylene Blue Nasal Spray

• May improve focus, memory, and cognitive clarity
• May reduce stress and enhance mood, especially during peri/menopause
• May offer neuroprotective and cortisol-lowering effects
• May support skin health and hormonal balance

• 2 sprays in each nostril in the morning

12 months

Oxytocin: 

• Receptor Binding and Signal Transduction:
  • Oxytocin exerts its physiological effects by binding to the oxytocin receptor (OXTR), a G-protein–coupled receptor (GPCR) expressed on target cells in the brain, uterus, mammary glands, and cardiovascular system. Receptor activation stimulates phospholipase C (PLC), leading to the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP₂) into inositol triphosphate (IP₃) and diacylglycerol (DAG). This cascade elevates intracellular calcium (Ca²⁺) levels, initiating downstream contractile and signaling responses.

• Cellular Activation and Physiologic Response: 
  • Increased intracellular calcium activates calmodulin-dependent kinases and the cell’s contractile machinery, producing smooth muscle contractions, most notably in uterine and mammary tissues. This mechanism underlies oxytocin’s role in labor induction, postpartum uterine tone, and milk ejection during lactation.

• Neuroendocrine and Behavioral Regulation:
  • Beyond its peripheral actions, oxytocin functions as a neuropeptide in the central nervous system, influencing social bonding, trust, emotional regulation, and sexual behavior. It modulates activity in limbic and hypothalamic brain regions associated with emotional processing and stress adaptation.

• Stress Reduction and Parasympathetic Activation:
  • Oxytocin dampens hypothalamic-pituitary-adrenal (HPA) axis activity, lowering cortisol levels and promoting a parasympathetic, restorative state. These effects contribute to reduced anxiety, enhanced mood, and improved stress resilience.

• Systemic and Therapeutic Effects:
  • Through its dual roles as a hormone and neuromodulator, oxytocin supports reproductive physiology, emotional connection, and autonomic balance. Its actions on smooth muscle tone, cardiovascular regulation, and social cognition make it a unique peptide bridging endocrine and behavioral health.

Methylene Blue:

• Redox Modulation and Hemoglobin Reduction:
  • Methylene Blue acts as a redox-active compound that facilitates the conversion of methemoglobin (Fe³⁺) back to its functional ferrous form (Fe²⁺). By serving as an artificial electron carrier, it donates electrons to the NADPH–methemoglobin reductase pathway, restoring hemoglobin’s oxygen-binding capacity and improving oxygen transport and tissue oxygenation.

• Enhancement of Cellular Respiration: 
  • Beyond its hematologic effects, Methylene Blue supports mitochondrial respiration by shuttling electrons within the electron transport chain (ETC), particularly between complexes I and III. This bypasses dysfunctional segments of the ETC, enhancing ATP synthesis and improving mitochondrial efficiency under oxidative or hypoxic stress conditions.

• Antioxidant and Neuroprotective Actions:
  • Through its redox cycling, Methylene Blue reduces the accumulation of reactive oxygen species (ROS) and protects neuronal and mitochondrial membranes from oxidative injury. These properties contribute to neuroprotection, mitochondrial stabilization, and improved cognitive performance in stress or hypoxia-related dysfunction.

• Anti-Inflammatory and Cytoprotective Effects:
  • Methylene Blue exhibits mild anti-inflammatory properties by downregulating nitric oxide synthase (NOS) activity and NF-κB–mediated inflammatory signaling, helping reduce oxidative and inflammatory damage at the cellular level.

• Systemic Impact:
  • By restoring hemoglobin functionality, enhancing mitochondrial respiration, and reducing oxidative stress, Methylene Blue improves cellular energy production and tissue oxygen delivery. Its unique redox-modulating mechanism supports both neurological performance and metabolic resilience, making it a valuable adjunct in mitochondrial and cognitive optimization protocols.

• Disclaimer: For Research Purposes Only – All products on this site are for Research and Development use only. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease. Celia Health is a supplier of research-use chemicals manufactured in a CGMP facility in the US. Celia Health  is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act.