Klotho 10mg Lyophilized Powder: Automatic Refills

• Enhances cognitive function
• Promotes longevity and healthy aging
• Improves kidney function and calcium homeostasis
• Increase anti-aging skin regeneration and tightening
• Lowers inflammation throughout body
• Boosts Libido
• Supports fertility
• Provides brain neural pathway regeneration
• Increase nervous system repair
• Lowers blood pressure
• Reduces the progression of neurodegenerative disease
• Diminishes epigenetic disease expression
• Boosts energy levels

• Administer 0.5mL each dose
• Three times per week (M,W,F)

• • Duration: 12 months
    • 3 months on, 30 day break, 3 months on, 30 day break, 6 months on
  • Intramuscular injection
  • Administration and Reconstitution Instructions

Download Instructions

• Klotho-FG Axis and FGF Signaling
  • FGF23 (with α-Klotho) – Regulation of Phosphate and Calcium Metabolism
    • Produced by bone osteocytes and acts on the kidneys
    • Requires α-Klotho to bind to FGFRs and suppress renal phosphate reabsorption and vitamin D synthesis
  • FGF19 and FGF21 (with β-Klotho) – Metabolic Regulation
    • FGF19: Regulates bile acid metabolism, reduces bile acid synthesis, increases glycogen storage, and improves insulin sensitivity
    • FGF21: Enhances glucose uptake, increases lipolysis and fatty acid oxidation, and promotes thermogenesis
• Binding and Signal Transduction
  • Klotho as a Co-Receptor
    • Klotho proteins increase FGF binding affinity to FGFRs
    • Forms FGFR-Klotho-FGF complex that stabilizes receptor-ligand interaction
  • FGFR Activation
    • Ligand binding induces FGFR dimerization and autophosphorylation
  • Activates intracellular pathways:
    • MAPK/ERK – regulates gene expression for metabolism and growth
    • PI3K/AKT – promotes cellular survival and energy metabolism
    • STAT – regulates inflammatory response and cell proliferation
• Biological Effects
  • Phosphate and Calcium Regulation (FGF23 + α-Klotho)
    • Decreases renal phosphate reabsorption by downregulating Na+/Pi cotransporters
    • Suppresses 1,25-dihydroxyvitamin D production, reducing calcium and phosphate absorption in the gut
  • Metabolic Regulation (FGF19/FGF21 + β-Klotho)
    • FGF19: Inhibits bile acid synthesis, increases glycogen storage, reduces gluconeogenesis
    • FGF21: Enhances glucose uptake, stimulates fatty acid oxidation and thermogenesis

• Disclaimer: For Research Purposes Only – All products on this site are for Research and Development use only. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease. Celia Health is a supplier of research-use chemicals manufactured in a CGMP facility in the US. Celia Health  is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act.